Everything you need to know about HGH

Human Growth Hormone (HGH), also known as somatotropic hormone, is a 191 amino acid polypeptide produced in the pituitary gland. It plays a crucial role in the growth and maintenance of tissues throughout life, transforming a baby into a fully grown adult and sustaining tissue health over the years.

The Role of HGH in Muscle Growth and Fat Loss

Does HGH directly cause muscle growth? Not exactly. But is HGH anabolic for muscles? Absolutely. Can it aid in fat loss? Definitely. Does it assist in injury recovery and joint health? Yes, indeed.

What Happens When You Inject HGH or When Your Body Produces It?

The process can be quite complex, but here’s a simplified explanation:

After HGH is injected or released from the pituitary gland, it travels through the bloodstream. It cannot directly bind to muscle cells due to its large and complex structure. Instead, it activates satellite and stem cells in muscle tissue, preparing the nuclei to donate nuclear material, which is vital for muscle growth.

Growth is energy-intensive. HGH stimulates the release of glucagon, which mobilizes stored sugar from the liver and a small amount from muscle tissue into the bloodstream, raising blood sugar levels. This provides the necessary fuel for growth.

Additionally, HGH triggers the pancreas to release lipase, which breaks down stored fat in adipose tissue and releases it into the blood, increasing blood triglycerides. This process ensures the bloodstream is rich in energy, ready to fuel cell growth.

As blood sugar rises, the pancreas releases insulin to regulate it. After 60 to 90 minutes, the liver starts breaking down HGH, producing somatomedins, including IGF-1, which promotes cell growth and muscle hypertrophy.

Dosage Protocols for HGH

Starting Dosage:

• A typical starting dose is 2 IU per day for 5 days on, 2 days off. This schedule minimizes side effects like water retention and peripheral neuropathy (numbness or pain in the hands or feet).

For Hypertrophy:

• The best time to dose is before bed, aligning with the body's natural GH pulse during sleep. For doses above 4 IU per day, split the dose (e.g., 2 IU post-workout and 4 IU before bed).

For Fat Loss:

• Dose first thing in the morning, fasted, followed by a few hours of fasting and cardio. A second dose can be taken pre-workout. For a combined approach, split the dose between morning and before bed.

Reconstitution and Storage

HGH usually comes in powder form in vials, commonly containing 10 IU each, and should be stored in the fridge. Reconstitute with bacteriostatic water (1 ml for a 10 IU vial). Inject 1 ml of air into the vial before slowly adding the bac water. Gently roll the vial until the powder dissolves; do not shake. Reconstituted HGH lasts about 4 weeks in the fridge.

Side Effects and Mitigation

Water Retention:

• Common due to upregulation of the renin-angiotensin-aldosterone system (RAAS). The 5 days on, 2 days off protocol helps reduce this. ARBs like Telmisartan or ACE inhibitors can also help.

Gynecomastia (Gyno):

• Caused by increased prolactin levels. Lowering prolactin with cabergoline or vitamin B6 (200-400 mg per day) can mitigate symptoms.

Neuropathy:

• Symptoms include carpal tunnel-like numbness and tingling. The 5 days on, 2 days off protocol helps. Supplements like taurine (5-10 g/day), vitamin C (500-1000 mg/day), and vitamin B6 (100 mg three times a day) can reduce symptoms. If symptoms persist, cycling off HGH may be necessary before resuming at a lower dose.

FAQs

Should I wait after eating to dose HGH before bed?

• No, you can eat right before taking HGH. Nutrients in the blood will aid muscular growth.

Will taking HGH suppress my natural production?

• Yes, HGH suppresses natural production for about 8 hours. Dosing before bed ensures your body resumes production by morning.

Is there a risk of developing insulin resistance?

• Yes, due to elevated blood glucose levels. Taking metformin (500 mg daily with breakfast) can prevent this by improving insulin sensitivity and offering additional health benefits.

HGH, when used correctly, can significantly enhance muscle growth, aid in fat loss, and improve recovery. Always consult with a healthcare professional before starting any new supplementation protocol.